Collecting saliva in order to identify biomarkers associated with orofacial pain is a painless method and is easy to collect and store. Several studies report substance P, a neuropeptide associated with inflammation status and pain, as well as the stress hormone cortisol, and markers of oxidative stress can be repeatedly detected within salivary secretions [95, 96]. The number of total protein increases in the salivary secretion through β-sympathetic activity in the salivary glands, since saliva secretion is mainly evoked by the action of adrenergic mediators [19]. Recent advances in inorganic nanomaterials for wound-healing applications ... to inform and encourage scientists and young researchers globally to engage with this expanding area of biology and medicine. C. González-Cabezas, C.E. These fluids proved to have found widespread clinical applications in order to diagnose and monitor human health. Until now, nearly all established SPR instrumentation schemes are based on single- or several-channel configurations. doi: 10.1016/j.oooo.2014.03.006. Dentistry is the branch of medicine that is involved in the research, diagnosis, prevention and treatment of disorders, diseases and conditions related to dental and oral cavity. 2007;103:412-417. Advances in dental care are making procedures faster, longer lasting, and easier on patients. CiteScore: 4.1 ℹ CiteScore: 2019: 4.1 CiteScore measures the average citations received per peer-reviewed document published in this title. 1566 Articles. An accurate analysis of the human saliva proteome can be related to the general health status. Updated August 5, 2018. The most commonly assayed salivary biomarkers are cortisol, testosterone, progesterone, aldosterone, and hydroxyprogesterone [3]. Zhang, X.-Q. Risk factors in the development of Alzheimer’s disease are systemic infections [71], brain infections due to bacteria or virus involvement [72], but the association of various antimicrobial peptides in this disease is still not completely clear. Until now, it can be considered that limitations 1 and 3 have found solutions with the help of salivary biomarkers and an ongoing development of salivary diagnosis [2]. Research Impact Recent Advances. One of the most appealing diagnostic tools is thought to be the human saliva, holding the key to an early diagnosis, a better treatment, and an improved prognosis [1]. This activity will provide recent updates in the fields of neurology, rheumatology, the role of immunotherapies in oncology and wellness/brain health by … 2019 Recent advances in medicine and surgery. At the beginning of the inflammatory phase, prostaglandin E2, interleukin-1, interleukin-6, and tumor necrosis factor-alpha are found in a high number, released from a variety of cells [25]. In this review article, we mainly focus on highlighting the role of inorganic nanomaterials and nanomaterial-based approaches for wound healing and tissue … The authors declare that there is no conflict of interest regarding the publication of this paper. Early diagnosis is an important aspect regarding this type of cancer knowing the fact it is the most common cause of death in men and women. Georgios Tsoulfas Petros I. Bangeas and Jasjit S. Suri synthesize state-of-the-art information on 3D printing and provide guidance on the optimal application in today’s surgical practice from evaluation of … New technologies have proven their efficacy and unveiled a large number of salivary biomarkers that are connected to several general and oral diseases [5]. For instance, the genetic variations present in a breast cancer patient can be identified by a simple blood test, thereby allowing for selection of … CiteScore: 3.1 ℹ CiteScore: 2019: 3.1 CiteScore measures the average citations received per peer-reviewed document published in this title. For instance, the effects of disease and sedation on pain scoring/ assessment are unknown. Journal of Advanced Research in Medical Science and Technology - Volume 1 - 2014. omes. ADA-funded researchers use the money from their awards to conduct critical diabetes research. This specific term gathers all the technologies used for analyzing potentially salivary biomarkers: proteomics, genomics, transcriptomics, microRNA (miRNA), and metabonomics [10]. Feb 2018 - … Pharmacogenomics is a therapeutic field that helps in identifying the genes that affect drug response in a patient. Also, salivary macrophage inflammatory protein-1α, matrix metalloproteinase-8, interleukin- (IL-) 1β, IL-6, prostaglandin E2, and tumor necrosis factor- (TNF-) α levels seem to be associated with gingivitis and periodontitis, having a high potential to be used in their diagnosis [45]. After over 40 years of neglect, two new drugs (bedaquiline and delamanid) have been made available to manage difficult-to-treat MDR-/XDR … Tumoral surgical pathology of the parotid gland: National Cancer Institute of Colombia, A hybrid nasal intubation technique for the head and neck surgical patient: a case series and review of the literature, Tetrafocal intraoral bone transport for mandibular reconstruction combined with free fibula flap and mandibular zygomatic implants, Intraoral labial frenulectomy with periosteal release: a simple approach to enhance immediate surgical outcome and long-term stability of the cosmetic rhinoplasty, Retrospective study of zygomatic complex fractures treated by transconjunctival approach: our experience, on behalf of Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer. Li et al., “Saliva in the diagnosis of diseases,”, M. A. Javaid, A. S. Ahmed, R. Durand, and S. D. Tran, “Saliva as a diagnostic tool for oral and systemic diseases,”, D. B. Ferguson, “Current diagnostic uses of saliva,”, P. C. Fox, P. F. van der Ven, B. C. Sonies, J. M. Weiffenbach, and B. J. Baum, “Xerostomia: evaluation of a symptom with increasing significance,”, D. L. Korte and J. Kinney, “Personalized medicine: an update of salivary biomarkers for periodontal diseases,”, O. Brinkmann, L. Zhang, W. V. Giannobile, and D. T. Wong, “Salivary biomarkers for periodontal disease diagnostics,”, T. Yucel-Lindberg and T. Bage, “Inflammatory mediators in the pathogenesis of periodontitis,”, D. T. Graves and D. Cochran, “The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction,”, S. Kwan Tat, M. Padrines, S. Theoleyre, D. Heymann, and Y. Fortun, “IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology,”, H. E. Barksby, S. R. Lea, P. M. Preshaw, and J. J. Taylor, “The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders,”, P. Stashenko, F. E. Dewhirst, W. J. Peros, and R. L. Kent, “Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption,”, S. P. Engebretson, J. T. Grbic, R. Singer, and I. Mike Floorwalker . Copyright © 2019 Alexandra Roi et al. Nefzi et al. Learn more from WebMD. ], Clinical pathologic conference case 1: firm erythematous gingival mass, Clinical pathologic conference case 2: a rapidly growing palatal mass in a man with HIV, Clinical pathologic conference case 3: multiple deep oral ulcers, Usefulness of contrast-enhanced dual-energy computed tomography for detecting oral, head, and neck cancers, Introduction of a ROTEM-assisted strategy improves patient blood management in children undergoing open craniosynostosis repair, Review of orbital fractures in an urban level I trauma center, Prophylactic scheme with parenteral and oral dexamethasone for the control of edema, pain, and trismus after surgery on the wisdom teeth, Biomechanical evaluation of mandibular fixation techniques in patients with obstructive sleep apnea: a human cadaveric study, Improvement of periorbital appearance in Crouzon syndrome after subcranial Le Fort III osteotomy with facial bipartition and an internal distractor device: a retrospective study. Research proved the high potential of the salivary biomarkers and their diagnostic capability, promoting it with uncontestable advantages over other body fluids. 1. Here are the top 10 new medical technologies in 2019: Modern ASD products noninvasively treat a range of chronic diseases (for example, hepatitis C, cystic fibrosis, and HIV). Response to: “Modified compartmental resection—is mandibulotomy access justified?”, Erratum to “Spontaneous Osteosarcoma in Craniomaxillofacial Fibrous Dysplasia: Clinical and CT imaging Features in 8 Cases” [Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118(1):e24-31. Salivary biomarkers have the potential to help the early diagnosis without using CT [84]. European Journal of Anaesthesiology: June 2019 - Volume 36 - Issue 6 - p 470-471. doi: 10.1097/EJA.0000000000000978. This article provides an update on the most recent advances in diagnostic procedures and therapeutic … 1566 Open Access. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. Minor salivary glands that are situated in the connective tissue below the circumvallate papillae are Von Ebner glands, and the mucous ones are Blandin-Nühm glands [13]. It was shown the fact that this syndrome is accompanied with significant changes in the proteome and transcriptome, having also important alterations in the levels of IL-4, IL-5, and cytokine clusters [32]. The tissues that are found in the orofacial region are heterogeneous, a fact that makes the treatment of pain conditions a challenge for the clinician. More studies in salivary proteins showed the fact that saliva contains actually hundreds of minor proteins or peptides that although are present in variable concentrations can have a significant role in the diagnosis of diseases; these proteins can receive the role of biomarkers in relation to specific conditions. Chronic pain in cats: Recent advances in clinical assessment. Santamaria, J. Schmoeckel, C.H. Another important research identified 19 genes (EPSTI1, IFI44, IFI44L, IFIT1, IFIT2, IFIT3, MX1, OAS1, SAMD9L, PSMB9, STAT1, HERC5, EV12B, CD53, SELL, HLA-DQA1, PTPRC, B2M, and TAP2) that were correlated with this syndrome and were responsible for the induction of interferons and antigen presentation [49]. CiteScore values are based on citation counts in a range of four years (e.g. The use of saliva as a diagnostic fluid has gained attention in the past few years, and researches have proved the high sensitivity of this type of diagnosis regarding the detection and prediction of diseases. Treat-to-target approach. Park, H. Zhou, D. Elashoff et al., “Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection,”, M. A. R. St John, Y. Li, X. Zhou et al., “Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma,”, Y. Li, M. A. St John, X. Zhou et al., “Salivary transcriptome diagnostics for oral cancer detection,”, R. Nagler, G. Bahar, T. Shpitzer, and R. Feinmesser, “Concomitant analysis of salivary tumor markers. 2019. The focus is on providing information about the important salivary constituents, the mechanism of using saliva as a diagnostic tool, and the clinical applications that can influence an early diagnosis. The aim of the research initiated by Song et al. Recent Advances in Remineralization Therapies for Caries Lesions. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. In saliva, the tumor-specific DNA was positive in 100% of the patients diagnosed with oral cancer, and 47-70% of the patients with tumors in other places of the body also carry specific tumor DNA markers in the saliva [21]. 10 Recent Biotechnology Advances In Medicine. It is said that saliva reflects the “body’s health” and well-being, but until recently its use as a diagnostic tool has been hindered because the examination of the biomolecules that exist in saliva and their relevance and association with different etiologies has been not enough explored [4]. Salivary diagnostics has received attention due to its connections to various high-impact systemic diseases and physiological conditions that were shown to have an influence in the composition of saliva. The entire activity of IL-1 is based on interleukin-1alpha and interleukin-1beta (was proved to be elevated in association with periodontitis) [31–33]. 20 MNiSW 2019. Alzheimer’s disease (AD) is one of the most common neurovegetative disorders that occur to the aging population. 2000-2020 Available between "Advances in Respiratory Medicine" (ARM) is an international title that replaced "Pneumonologia i Alergologia Polska" at the fall of 2016. 1566 Articles. M. Alkilzy, R.M. As the stages progress and the disease becomes more advanced with severe bone loss, the levels of tumor necrosis factor, interleukin-1, and RANKL are elevated and directly related to the degree of bone destruction [25]. The definition of a biomarker refers to a pharmacological or physiological measurement that can be used to predict a toxic event, in this specific case a molecule that contains particular material that can be used in order to diagnose a disease or measure the progression and treatment outcome. The first choices in the analysis are the proteomic constituents, but genomic targets can be a valuable source of biomarkers also. Until now, many studies have been performed focusing on the salivary biomarkers in Alzheimer’s disease and only a few regarding the salivary cholinesterase enzyme. B. Lamster, “GCF IL-1-beta profiles in periodontal disease,”, U. K. Gursoy, E. Könönen, P. J. Pussinen et al., “Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach,”, S. Becerik, N. Özsan, A. Gürkan, V. Ö. Öztürk, G. Atilla, and G. Emingil, “Toll like receptor 4 and membrane-bound CD14 expressions in gingivitis, periodontitis and CsA-induced gingival overgrowth,”, P. P. Costa, G. L. Trevisan, G. O. Macedo et al., “Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes,”, M. Geivelis, D. W. Turner, E. D. Pederson, and B. L. Lamberts, “Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease,”, S. Liskmann, T. Vihalemm, O. Salum, K. Zilmer, K. Fischer, and M. Zilmer, “Correlations between clinical parameters and interleukin-6 and interleukin-10 levels in saliva from totally edentulous patients with peri-implant disease,”, G. Schierano, G. Bellone, E. Cassarino, M. Pagano, G. Preti, and G. Emanuelli, “Transforming growth factor-, C. S. Miller, J. D. Foley, A. L. Bailey et al., “Current developments in salivary diagnostics,”, J. S. Kinney, T. Morelli, T. Braun et al., “Saliva/pathogen biomarker signatures and periodontal disease progression,”, C. A. Ramseier, J. S. Kinney, A. E. Herr et al., “Identification of pathogen and host-response markers correlated with periodontal disease,”, T. Sorsa, L. Tjäderhane, Y. T. Konttinen et al., “Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation,”, M. al-Sabbagh, A. Alladah, Y. Lin et al., “Bone remodeling-associated salivary biomarker MIP-1, H. D. Jenifer, S. Bhola, V. Kalburgi, S. Warad, and V. M. Kokatnur, “The influence of cigarette smoking on blood and salivary super oxide dismutase enzyme levels among smokers and nonsmokers—a cross sectional study,”, J. L. Ebersole, R. Nagarajan, D. Akers, and C. S. Miller, “Targeted salivary biomarkers for discrimination of periodontal health and disease(s),”, M. K. Hendek, E. O. Erdemir, and U. Kisa, “Evaluation of salivary procalcitonin levels in different periodontal diseases,”, S. Banu, N. R. Jabir, R. Mohan et al., “Correlation of toll-like receptor 4, interleukin-18, transaminases, and uric acid in patients with chronic periodontitis and healthy adults,”, D. C. Matthews, K. McNeil, C. A. McCulloch, and M. Glogauer, “Adoption issues associated with a new periodontal screening tool: an online survey of Canadian dentists,”, S. A. Khuder, I. al-Hashimi, A. The use of this method brings to light an efficient and easy approach that can improve considerably the diagnosis, prognosis, treatment, and post-therapy monitoring. The strive is to bridge laboratory and clinical settings with … Salivary diagnostics with the help of biotechnologies made it possible for several biomarkers to be associated with multiple diseases such as cancer, autoimmune diseases, viral diseases, bacterial diseases, cardiovascular diseases, and HIV. Recent Advances in Pathology & Laboratory Medicine … It is supposed that the process of Alzheimer’s is initiated years before it becomes clinically manifest [65]. Pharmacogenomics can help in speeding up the process of treating a disease. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. Orofacial pain is a sensory experience within a specific anatomical region and can be related to some common chronic orofacial entities: TMJ myalgia and arthralgia, atypical odontalgia, persistent dentoalveolar pain disorder, burning mouth syndrome, persistent idiopathic facial pain, neuralgia of the head and neck, and primary headache syndromes [87]. Advances in Diagnosis and Treatment of Sleep Apnea and Snoring February 15-17, 2019 ... to provide a comprehensive review and update on recent advances in the diagnosis and management of sleep apnea and snoring. Monteiro BP(1)(2), Steagall PV(2). These specific tests have the aim at identifying the p24 antigens and antibodies against HIV-1 and HIV-2. The delay in the use of saliva as a diagnostic method was mainly because until recent there has been a lack of understanding of the biomolecules that were found in the saliva. In surgical rooms, doctors can now operate on patients remotely from their computer screens, guiding robotic arms to an accuracy of a few nanometers. However, saliva is considered to have an enormous potential of biomarkers that range from changes in biochemical, DNA, RNA, and proteins to the oral environment. Epub 2019 May 7. [61] show that the salivary levels of IL-1β, IL-6, TNF-α, and prostaglandin E2 are increased in atherosclerosis, suggesting that these cytokines could be potential biomarkers in the diagnosis of atherosclerosis. Scully CM. Saliva has been used in studies as a diagnostic tool for oral squamous cell carcinoma (OSCC) based on the help of salivary analytes (proteins, mRNA, and DNA) [1]. by Sashi Mahato in Biomedical. Until now, nearly all established SPR instrumentation schemes are based on single- or several-channel configurations. Ultimately, this cycle drives advances to prevent diabetes and to help people burdened … Serious investments were made, motivating scientists, governments, and industry to direct resources in the saliva diagnostics [2]. The M. D. S. in Oral Medicine & Radiology is a three year Postgraduate program. A. de Lima, and L. R. Azevedo, “Saliva composition and functions: a comprehensive review,”, M. Carranza, M. E. Ferraris, and M. Galizzi, “Structural and morphometrical study in glandular parenchyma from alcoholic sialosis,”, S. Hu, P. Denny, P. Denny et al., “Differentially expressed protein markers in human submandibular and sublingual secretions,”, J. K. M. Aps and L. C. Martens, “Review: the physiology of saliva and transfer of drugs into saliva,”, Z. T. Dame, F. Aziat, R. Mandal et al., “The human saliva metabolome,”, A. With the help of a standardized collection procedure and protocol, the use of salivary biomarkers for different orofacial pain disorders is a promising diagnostic method that will allow for a noninvasive approach. 55. Currently, several salivary tests are available based on the proteomic analysis of the saliva and the existing antibodies for hepatitis A, B, C viruses, HIV-1, rubella virus, mumps virus, and others [21]. We made a mini review of recent … Regarding the periodontal pathogenic processes, periodontitis can be classified based on the three phases of evolution: inflammation, connective tissue degradation, and bone turnover. RT has advanced in both methodological and biological aspects over the past few decades. CT is being used for routine screening for early lung cancer, with the disadvantage of a high false-positive rate [83]. Early diagnosis and treatment is the key to a good prognosis in almost all types of cancer. Eur Rev Med Pharmacol Sci 2019; 23 (21): 9445-9453 DOI: 10.26355/eurrev_201911_19438 Recent advances of nano-drug delivery system in oral squamous cell carcinoma treatment Naitoh M, Suenaga Y, Kondo S, Gotoh K, Ariji E. Assessment of maxillary sinus septa using cone-beam computed tomography: etiological consideration. More recently, a new oral rinse system has been developed that can effectively estimate the number of neutrophils found in the saliva in order to certify the existence of periodontal disease [48]. Cardiovascular disease (CVD) includes atherosclerosis, coronary heart disease, and myocardial infarction. The effective contribution of genomic and proteomic technologies made possible for saliva to become an attractive solution to other invasive diagnostic methods. This association suggests that this hormone can be used as a marker for clinical staging [60]. At the time, saliva is most frequently used as a diagnostic tool for systemic diseases and the future relies in combinations of different biomarker panels that can be used for screening in order to improve the early diagnosis and the general outcome [4]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. The oral fluid also can contain food debris and blood-derivated compounds such as plasmatic proteins, erythrocytes, and leucocytes in case there is inflammation present [3]. Program Overview. The study performed by Jasim et al. Human saliva has a specific proteomic content that allows researchers to perform assays in order to discover novel saliva biomolecules associated with general health status. These types of biomarkers from the transcriptome and proteome can provide in the future a simple diagnostic tool for SS. Another S1P receptor modulator, etrasimod, was recently shown to be effective for clinical response, clinical remission and … The studies performed by Kosaka et al. Oral cancer is the sixth most common cancer type worldwide, and 90% is represented by OSCC. Systemic diseases are very challenging to diagnose without more invasive supplementary investigations. These kinds of alterations and modified proteins can be specific in some diseases such as autism spectrum disorder [7] and cervical cancer [8]. Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines.. The most amazing medical breakthroughs of 2019 By ... which showcases the world’s biggest cancer advances. Bruton’s tyrosine kinase (BTK) regulates the functions of B cells and myeloid cells that are implicated in the pathogenesis of multiple sclerosis. 2019, Article ID 8761860, 11 pages, 2019. https://doi.org/10.1155/2019/8761860, 1Department of Oral Pathology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 2Department of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 3Department of Oral Rehabilitation and Dental Emergencies, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 4Department of Periodontology, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania. A good method for salivary diagnostics should have general functionality, high sensitivity and specificity, low cost, and efficient clinical application. 106 Issues. CA 125 is a tumor-associated antigen that was found in high levels in the saliva of the patients with oral, breast, and ovarian cancer [59]. Describe recent advances in oral routes of drug administration. Researchers that focused on the study of human saliva have characterized 4 major types of salivary proteins: PRPs, cystatins, statherins, and histatins. Possible through antibody-based screening assays: 2019: 3.1 ℹ citescore: 2019: 3.1 citescore measures the citations. Inflammation process associated with periodontitis is interleukin-1 expression showed great variations between different saliva collection methods 6. For salivary diagnostics should have general functionality, high sensitivity and specificity, low,! An alternative diagnostic tool, with the disadvantage of a new recent advances in oral medicine 2019, (... A step up in severity ( and consequences ) from CRISPR and other gene-editing tools medications vary national. 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